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Abstract

In 1998, 16.6 and 10.1% of patients died of heart and cerebrovascular diseases respectively. The main disease process is underlying atherosclerosis. In the coronary arteries, rupture or fissure of a vulnerable plaque is followed by thrombosis, with acute narrowing of the coronary artery that results in acute coronary syndrome (ACS).1 The key to thrombotic occlusion is the platelets, which can be activated by multiple mechanisms including thromboxane A2 , ADP, thrombin, collagen, and others. Once activated, platelet thrombus will be formed by fibrinogen binding to IIb/IIIa receptors.

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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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