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Abstract

BACKGROUND: This study aimed to provide local data with respect to clinical outcomes such as HF-related hospitalization and clinical symptom occurrence and side effect profile. OBJECTIVES: The objectives were to evaluate Sacubitril/Valsartan’s impact on the number of HF-related hospitalization; to describe the local prescribing pattern of Sacubitril/Valsartan in terms of initiation regime and mean daily maintenance dose; and to report the documented side effects resulted from Sacubitril/Valsartan use if any. METHODS: This study was a retrospective, single-centered and noninterventional review carried out in Princess Margaret Hospital. Patients initiated with Sacubitril/Valsartan as a Special Drug were included. The study period was six months pre- and post- Sacubitril/Valsartan initiation. RESULTS: 131 patients were included with a mean age of 66.4 ± 11.3 years old. Post- Sacubitril/Valsartan initiation period had a significantly lower number of HF-related hospitalization per patient per month than pre-Sacubitril/Valsartan initiation period (0.113 ± 0.139 versus 0.048 ± 0.150; P < 0.001). The documentation rates of shortness of breath (69% versus 31%, P < 0.001) and lower limbs edema (40% versus 17%, P < 0.001) were also lower in the post- Sacubitril/Valsartan period. Sacubitril/Valsartan initiation showed an elevated serum potassium level (4.02 ± 0.40 versus 4.11 ± 0.40 mmol/L, P = 0.010). Mean total daily dose of Sacubitril/Valsartan at the end of follow-up period was 125 ± 67 mg. CONCLUSION: Use of Sacubitril/Valsartan reduced the rate of HF-related hospitalizations, documentation rates of shortness of breath and lower limbs edema, when compared with the same group of patients before Sacubitril/Valsartan initiation

Keywords: Sacubitril/Valsartan; Heart failure; Heart failure-related hospitalization; Hong Kong; Angiotensin Receptor-Neprilysin Inhibitor

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